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Besides being the wife of Mr. Roddenberry, she was well known to fans as Nurse Chapel in the original series, Lwaxana Troi in Star Trek: The Next Generation and Star Trek: Deep Space Nine, and the voice of all Federation computers since The Next Generation. As if all that wasn’t enough, she also did voices for the Star Trek cartoon series, appeared in other shows such as Leave It To Beaver and Babylon 5 and on, and on, and on. She was never a woman to sit around quietly.
After Gene passed in 1991, every one looked to her for her blessing on all subsequent Star Trek projects, though she lacked any ability to stop one from happening. She was considered “the First Lady of Star Trek”, though I generally heard her referred to as “Mom” by many fans.
I had the pleasure of meeting Mrs. Barrett-Roddenberry on numerous occasions at San Diego Comic Con, the Star Trek 30th Anniversary convention in Huntsville, AL and so on, and I can honestly say she was never anything but pleasant and cordial. If you took the time to talk to her, she gave you her undivided attention and expressed as much interest as she could in what you had to say to her. I have met many celeberties over the years through my various jobs and connections, and I have to say she ranked easily as one of my favorites for just how nice she was.
She was scheduled to be the voice in the upcoming 2009 Star Trek film, but it is unclear if she had recorded her lines by the time of her passing. My feeling is she has recorded so many other clips, there is a good chance they could splice together what they need.
Rest in peace, Majel. You will be missed.